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Before you install an anti-virus scanner on your server, you should install ClamAV. You can get it up and running from scratch in about 10 minutes. Most Linux distributions' clamd.conf files are already configured to scan mail. Also, quite conveniently, most distros' ClamAV configurations are set to check for virus signature updates several times a day. ClamAV even has several SMTP scanners for sysadmins who want to make sure their users aren't sending anything infected.
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